Akiyoshi Fukamizu

METTL18 is Required for Developmental, Metabolic, and Endocrine Regulation of Mammalian Growth

ABSTRACT Histidine methylation is an evolutionarily conserved but poorly understood post‐translational modification. METTL18 is known to catalyze histidine N τ‐methylation in vitro, yet its physiological functions in mammals remain unclear. Here we show that mouse METTL18 possess...

DDI-4 induces a temperature-sensitive exocytotic remodeling during C. elegans spermiogenesis via nsun-2–dependent sphingosine signaling

Exocytotic sperm remodeling is essential for fertilization, yet whether conserved molecular mechanisms underlie this process across species remains unclear. In Caenorhabditis elegans , membranous organelle fusion (MOF), an exocytotic event cytologically analogous to the mammalian...