Akhilesh Pandey

Establishment and characterization of multiple myeloma cell lines from a single patient’s disease course immortalizes clonal heterogeneity

Abstract Multiple myeloma (MM) is an incurable plasma cell neoplasm characterized by diverse and complex genetic abnormalities, including translocations of immunoglobulin (Ig) genes and a hyperdiploid karyotype. Much of our current understanding of MM genetics, epigenetics, patho...

TRAIL splice variant TRAILshort disrupts T cell receptor signaling and promotes immune tolerance in vivo

TRAIL is a TNF family ligand that trimerizes TRAIL-R1 (DR4) or TRAIL-R2 (DR5) to induce apoptosis, necroptosis, and/or NF-κB activation in receptor-bearing cells. We previously identified TRAILshort as a splice variant of TRAIL that lacks cysteine 230, cannot trimerize, and acts...