Aimin Song

Unphosphorylated tyrosines mediate PD-1 inhibition of T cell signaling condensate formation

T cell receptor (TCR) engagement stimulates formation of a biomolecular condensate, including the scaffold protein linker of activated T cells (LAT). We investigated whether the immune-inhibitory receptor programmed cell death protein 1 (PD-1) inhibits by impeding TCR-induced LAT...

Discovery ofHighly Selective Noncovalent MacrocyclicPeptide Inhibitors Suppressing Both TMPRSS2 Protease Activity andViral Receptor Function

Abstract The type II transmembrane serine protease TMPRSS2 plays a critical role in respiratory virus entry, including SARS-CoV-2. Using an mRNA display platform with genetic code reprogramming, we identified macrocyclic peptide (MCP) inhibitors of TMPRSS2 that bound to the TMPRS...