Aigar Ottas

Impact of matched samples on domain harmonization in cross-cohort NMR metabolomics

INTRODUCTION: Machine learning models trained on metabolomics data frequently show reduced performance when applied to independent cohorts because of domain shifts introduced by differences in analytical platforms, sample handling, storage conditions, and metabolite quantificatio...

Comprehensive NMR metabolomic profiling reveals a pro-atherogenic signature in psoriasis

Abstract Psoriasis (PS) is a chronic inflammatory skin disease associated with cardiometabolic comorbidity. While systemic inflammation is recognized as a major driver of this risk, metabolomic signatures linking PS to cardiometabolic dysfunction remain incompletely defined. The...