AHMED SAEED AL GHAMDI

A Computational HIV-1 Sequential Immunization Series Targeting the VRC01 Germline Pathway

A five-dose sequential immunogen series designed to guide germline VRC01-class B cells toward the HIV-1 gp120 CD4-binding site. Designed and validated using AlphaFold, ProteinMPNN, and PDB structures 3NGB/5IES/5IDL. The series achieves pTM scores of 0.83-0.91 across all doses, wi...