Agnieszka B. Wisniewska

Cyclic Peptide PROTACs Restore VHL-Mediated HIF-1α Degradation in Hypoxia

Abstract We report a systematic approach to convert cyclic peptide protein–protein interaction (PPI) inhibitors into functional degraders. We compare traditional PEG-based linkers with custom bifunctional amino acids that embed a Von Hippel-Lindau (VHL)-recruiting ligand and vari...