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Simultaneous Quantification of Ketamine and Its Metabolites in Rat Plasma Using LC-MS/MS: Method Development, Validation, and Application

Ketamine (KE) is a clinically important anesthetic and toxicologically relevant compound that undergoes sequential metabolism to norketamine (NKE) and hydroxynorketamine (HNKE).Because parent-only measurements are insufficient to characterize KE disposition, the simultaneous quan...