Adriana Loverre

A dendritic cell autophagy–neutrophil axis limits intratumoral STING immunotherapy

The cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway promotes tumor immunogenicity, but intratumoral STING agonists, despite strong preclinical efficacy, have shown limited clinical efficacy. The mechanisms restricting therapeutic STING activation rem...