Aderbal S. Aguiar

The Ergogenic Effect of Caffeine in Rodents: A Systematic Review and Meta-Analysis, with a Narrative Synthesis of Adenosine A2A Receptor Mechanisms

Abstract Caffeine is a widely consumed ergogenic aid and a nonselective antagonist of adenosine receptors, including the facilitatory A2A subtype (A2AR), yet the magnitude of its performance-enhancing effect in rodents has not been formally quantified. We conducted a systematic r...

Purinergic P2X7 Receptor Antagonism Impairs Aerobic Capacity without Detectable Effect on Cardiac Adaptation to Exercise in Mice

Abstract Adenosine triphosphate (ATP) signaling through the P2X7 receptor is an emerging determinant of mitochondrial energy metabolism and physical fitness, and the receptor is increasingly targeted pharmacologically for its role in inflammation. Whether systemic P2X7 antagonism...