Adam P. Mecca

An Investigation of Sleep Macro‐ and Microarchitecture by APOE Genotype

Objectives Apolipoprotein E ε4 ( APOE ε4 ), a robust genetic risk factor for Alzheimer's disease (AD) is associated with functional connectivity deficits and amyloid pathology in brain regions involved in sleep regulation. Thus, alterations in sleep architecture may be one pathwa...