Adam E. Mullick

Hyperglycemia Drives an Activated, Lipid-Laden Nonclassical Monocyte Phenotype in Diabetes

The presence of lipid-loaded macrophages in the artery wall and kidney characterizes diabetic atherosclerotic cardiovascular disease and diabetic kidney disease, respectively. Monocytes, the bone marrow–derived precursors of macrophages, accumulate lipids in response to hyperchol...

Transient (Pro)renin receptor silencing disrupts proximal tubule development in human kidney organoids

The (pro)renin receptor [(P)RR] plays a crucial role in murine kidney development, but its function in human kidneys remains poorly understood due to the lack of suitable research models. Human induced pluripotent stem cell (iPSC)-derived kidney organoids recapitulate early kidne...