ABM Reazul Islam Zim

CDKN1B variant prioritization reveals Y74N as a highly destabilizing mutation and identifies regulatory SNPs linked to structural and transcriptional disruption

The CDKN1B -encoded tumor suppressor protein p27 Kip1 is a key regulator of the G1-S cell cycle checkpoint, and its dysregulation is implicated in human malignancies. However, a comprehensive in silico characterization of both coding and non-coding variants in this gene remains l...