Abigail G. Doyle

Machine Learning-Guided Scope Selection to Balance Performance and Substrate Similarity

Abstract The determination of a reaction substrate scope enables downstream users to assess whether a specific transformation is suitable for an intended application. The information content of this scope, characterized by its performance and structural diversity, is crucial to e...

DiploPhos: A Hemilabile Bisphosphine for Sterically Hindered Ni-Catalyzed Suzuki–Miyaura Couplings

Abstract Pharmaceutically relevant Suzuki–Miyaura cross-couplings (SMCs) often require designer phosphine ligands and palladium loadings above 1 mol % to couple Lewis basic, sterically congested substrates. Recent work has demonstrated that nickel is an attractive alternative to...