Abhay Kotecha

Mechanisms of intracellular pH gating and local anesthetic inhibition of the two-pore domain K + channel TASK-2

TWIK-related acid-sensitive K+ channel 2 (TASK-2) is a pH sensing two-pore K + (K2P) channel that regulates respiration in brainstem neurons and systemic pH homeostasis in kidney. Despite its physiological importance and implication in disease, the molecular basis for intracellul...