Abdul Wazid Shaik

De Novo Computational Design of DARPin Binders Targeting FcεRI Alpha Chain Domain 2 via Structure-Guided Sequence Optimisation, Multi-Seed Deep Learning Prediction and Interfacial Thermodynamic Validation

Abstract Background: Computational design of targeted protein binders against cell-surface receptorsremains a critical frontier in therapeutics and biotechnology. The high-affinity IgE receptoralpha chain (FcεRI) mediates the allergic inflammatory cascade by binding immunoglobuli...