Abdi Wira Septama

In Vitro and In Vivo Antiplasmodial Activities, Phytochemical Characterization, and Acute Oral Toxicity of Leaf Extracts of Blumea balsamifera

Blumea balsamifera is traditionally used in Thai herbal remedies for fever management; however, its antiplasmodial potential has not been comprehensively investigated. In this study, we evaluated the in vitro and in vivo antiplasmodial activities, phytochemical profile, and acute...

Design and synthesis of 6-chloro-1,3,5-triazine-2,4-diamine linked chalcone derivatives and their antimalarial activity evaluation

A series of nine triazine-chalcone hybrid compounds (7a–i) were designed and synthesized through a molecular hybridization strategy integrating 1,3,5-triazine and chalcone moieties. The hybrids were synthesized via sequential nucleophilic substitution reactions and characterized...