Abdelaziz A. Saber

Dynamic 99mTc-MIBI uptake and washout as functional biomarkers of glycyrrhizic acid-induced mitochondrial dysfunction and P-glycoprotein activity in HepG2 cells

OBJECTIVE: To investigate the effects of glycyrrhizic acid on HepG2 cell viability and the cellular uptake, retention, and washout kinetics of technetium-99m methoxyisobutylisonitrile (99mTc-MIBI), with particular emphasis on the potential involvement of mitochondrial function an...