Aarno V. Palotie

Systematic comparison of affinity plasma proteomic technologies across multiple cohorts reveals generalizability of proteomic prediction

Reference code for publication of study 'Systematic comparison of affinity plasma proteomic technologies across multiple cohorts reveals generalizability of proteomic prediction'.

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...