A Leder

A conserved tyrosine motif encodes a structural vulnerability controlling stability and activity across J-domain proteins

J-domain proteins (JDPs) direct Hsp70 functions through a conserved J-domain that engages and activates Hsp70. JDPs support proteostasis and are linked to development and disease, yet how they are regulated remains unclear. Here, we identify a conserved tyrosine motif outside the...